KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEPDC5
All Species:
15.76
Human Site:
S646
Identified Species:
38.52
UniProt:
O75140
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75140
NP_001007189.1
1572
177910
S646
N
M
A
E
L
Q
G
S
G
Q
R
D
P
T
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852875
773
87442
Cat
Felis silvestris
Mouse
Mus musculus
P61460
1527
173129
S604
N
M
A
E
L
Q
G
S
R
Q
R
D
P
T
H
Rat
Rattus norvegicus
NP_001100699
1456
164725
S572
D
S
M
S
L
N
F
S
G
T
E
E
L
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517877
828
93963
Chicken
Gallus gallus
XP_415249
1571
177723
S646
N
M
A
E
M
Q
D
S
G
Q
Q
D
L
T
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691450
1590
178752
S647
N
M
A
E
L
Q
G
S
E
Q
R
D
P
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728620
1472
168864
K588
D
P
S
Q
V
T
I
K
L
T
S
N
R
R
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794020
1608
181354
S657
S
L
V
V
K
L
T
S
N
R
R
R
W
T
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S9J6
2004
222187
A824
F
R
I
A
A
P
K
A
A
T
A
E
L
S
I
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
48
N.A.
91.7
87.4
N.A.
49.5
89.1
N.A.
75.5
N.A.
35.7
N.A.
N.A.
32.4
Protein Similarity:
100
N.A.
N.A.
48.6
N.A.
93.8
89.6
N.A.
50.9
94
N.A.
84.5
N.A.
53.7
N.A.
N.A.
48.6
P-Site Identity:
100
N.A.
N.A.
0
N.A.
93.3
20
N.A.
0
73.3
N.A.
80
N.A.
0
N.A.
N.A.
26.6
P-Site Similarity:
100
N.A.
N.A.
0
N.A.
93.3
40
N.A.
0
86.6
N.A.
80
N.A.
33.3
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
40
10
10
0
0
10
10
0
10
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
0
0
0
0
0
10
0
0
0
0
40
0
0
0
% D
% Glu:
0
0
0
40
0
0
0
0
10
0
10
20
0
0
0
% E
% Phe:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
30
0
30
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
40
% H
% Ile:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
10
0
10
10
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
40
10
0
0
10
0
0
0
30
0
0
% L
% Met:
0
40
10
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
40
0
0
0
0
10
0
0
10
0
0
10
0
0
0
% N
% Pro:
0
10
0
0
0
10
0
0
0
0
0
0
30
0
0
% P
% Gln:
0
0
0
10
0
40
0
0
0
40
10
0
0
0
0
% Q
% Arg:
0
10
0
0
0
0
0
0
10
10
40
10
10
10
20
% R
% Ser:
10
10
10
10
0
0
0
60
0
0
10
0
0
20
0
% S
% Thr:
0
0
0
0
0
10
10
0
0
30
0
0
0
40
0
% T
% Val:
0
0
10
10
10
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _